منابع مشابه
Synergism and Drug-receptor.
a Drugs A and B have similar activity. a -l When the effective doses of A and B in combination are located in the area of m+n 1, m> 1, n> 1, they are called par tial antagonism. a -4 When they are located out of the square area, that is, m)1...
متن کاملDrug synergism: its detection and applications.
Two drugs that produce overtly similar effects will sometimes produce exaggerated or diminished effects when used concurrently. A quantitative assessment is necessary to distinguish these cases from simply additive action. This distinction is based on the classic pharmacologic definition of additivity that, briefly stated, means that each constituent contributes to the effect in accord with its...
متن کاملReceptor Agonist Synergism in Obstructive Airway Diseases
For a long time it was believed that 2-adrenergic receptor agonists used in the treatment of obstructive airway diseases worked primarily on airway smooth muscle cells, causing relaxation, whereas glucocorticoids primarily improved airway function via their anti-inflammatory action, indicating that their clinical synergism occurred at the organism rather than the cellular level. However, it is ...
متن کاملDrug activity and therapeutic synergism in cancer treatment.
In work involving modeling of response surfaces to describe the effects of cancer chemotherapy treatments, it is important to define activity and therapeutic synergism in a statistically defensible manner. This requires the construction of confidence intervals around the estimated optimal treatment which has been achieved by use of an indirect method first proposed by Box and Hunter. Activity f...
متن کاملPerspectives in Pharmacology Drug Synergism: Its Detection and Applications
Two drugs that produce overtly similar effects will sometimes produce exaggerated or diminished effects when used concurrently. A quantitative assessment is necessary to distinguish these cases from simply additive action. This distinction is based on the classic pharmacologic definition of additivity that, briefly stated, means that each constituent contributes to the effect in accord with its...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1964
ISSN: 0021-5198
DOI: 10.1254/jjp.14.458